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货号: AR0002
规格
价格
货期
数量
20ul
￥600.00
In stock
0
40ul
￥1,100.00
In stock
0
100ul
￥2,260.00
In stock
0
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Customized service consultation
Carrier-free/conjugated antibody/large package or custom formula
主要信息
靶点
Nrf2
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,IP,ELISA
MW (kDa)
68kD（ Calculated）
100kD（ Observed）
宿主物种
Rabbit
同种型
IgG,Kappa
详细信息
反应性
IHC 1:1000-1:5000
WB 1:2000-1:10000
IF 1:200-1:1000
ELISA 1:5000-1:20000
IP 1:50-1:200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
理论分子量
68kD
实测分子量
100kD
克隆性
Monoclonal
克隆号
R370G
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抗原&靶点信息
基因名称:
NFE2L2 NRF2
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蛋白名称:
Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)
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别名:
Nuclear factor erythroid 2-related factor 2 ;
NF-E2-related factor 2 ;
NFE2-related factor 2 ;
HEBP1 ;
Nuclear factor, erythroid derived 2, like 2 ;
NF-E2-related factor 2 ;
NFE2-related factor 2 ;
HEBP1 ;
Nuclear factor, erythroid derived 2, like 2 ;
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细胞定位
Cytoplasmic, Nuclear
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组织表达
背景
nuclear factor, erythroid 2 like 2(NFE2L2) Homo sapiens This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015],
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功能
Domain:Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.,Function:Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.,PTM:Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.,subunit:Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.,tissue specificity:Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.,
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研究领域
>> >>Protein processing in endoplasmic reticulum ;
>> >>Parkinson disease ;
>> >>Pathways in cancer ;
>> >>Chemical carcinogenesis - reactive oxygen species ;
>> >>Hepatocellular carcinoma ;
>> >>Lipid and atherosclerosis ;
>> >>Fluid shear stress and atherosclerosis
>> >>Parkinson disease ;
>> >>Pathways in cancer ;
>> >>Chemical carcinogenesis - reactive oxygen species ;
>> >>Hepatocellular carcinoma ;
>> >>Lipid and atherosclerosis ;
>> >>Fluid shear stress and atherosclerosis
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信号通路
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