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货号: AH0001
规格
价格
货期
数量
20ul
￥540.00
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0
40ul
￥1,000.00
In stock
0
100ul
￥2,080.00
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0
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Customized service consultation
Carrier-free/conjugated antibody/large package or custom formula
主要信息
靶点
PD1
反应性
Human
应用
IHC,IF,ELISA
MW (kDa)
32kD（ Calculated）
56kD（ Observed）
宿主物种
Mouse
同种型
IgG1,Kappa
详细信息
反应性
IHC 1:200-400
IF 1:200-1:1000
ELISA 1:500-5000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
抗体验证策略
特异性
The antibody can specifically recognize human PD-1 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
理论分子量
32kD
实测分子量
56kD
克隆性
Monoclonal
克隆号
M699V
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human PD-1 AA range: 1-100
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基因名称:
PDCD1 PD1
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蛋白名称:
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
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细胞定位
Membranous, Cytoplasmic
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组织表达
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背景
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008],
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功能
developmental stage:Induced at programmed cell death.,Disease:Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Function:Possible cell death inducer, in association with other factors.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Monomer.,
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研究领域
>> >>Cell adhesion molecules ;
>> >>T cell receptor signaling pathway ;
>> >>PD-L1 expression and PD-1 checkpoint pathway in cancer
>> >>T cell receptor signaling pathway ;
>> >>PD-L1 expression and PD-1 checkpoint pathway in cancer
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信号通路
机体系统相关通路研究（Organismal Systems） >> 免疫相关通路（Immune-Related Pathways） >> T cell receptor signaling pathway（T 细胞受体信号通路）
人类疾病相关信号通路（Human Diseases） >> 肿瘤相关（Tumor-Related） >> PD-L1 expression and PD-1 checkpoint pathway in cancer（癌症中 PD-L1 表达与 PD-1 检查点通路）
细胞的环境信息应答相关信号通路（Environmental Information Processing） >> 血管生成与细胞黏附（Angiogenesis & Cell Adhesion） >> Cell adhesion molecules - 细胞黏附分子
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