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NF-kappa B signaling pathway - 核因子 κB 信号通路

炎症与免疫反应的核心调控通路，同时参与细胞存活、增殖与应激响应。静息状态下，NF-κB 二聚体（常见 p65/p50）与抑制蛋白 IκBα 结合，滞留于胞质；受刺激后（如 TNFα、LPS、IL-1β），IκB 激酶（IKKα/β/γ）被激活，磷酸化 IκBα 使其泛素化降解，NF-κB 二聚体入核，激活炎症因子（IL-6、TNFα、IL-1β）、趋化因子（CXCL8）、抗凋亡基因（Bcl-2、c-IAP）等靶基因表达。核心功能包括：启动先天免疫应答，清除病原体；调控炎症反应强度与持续时间；促进免疫细胞活化与存活；参与组织修复与应激适应。通路异常激活与多种炎症性疾病（类风湿关节炎、炎症性肠病、 sepsis）、自身免疫病、肿瘤（如淋巴瘤、肝癌中 NF-κB 持续激活）相关，IKK 抑制剂、NF-κB 抑制剂是潜在的治疗药物。
核心功能：核心炎症与免疫调控通路，激活后促进炎症因子、趋化因子表达，参与免疫应答与炎症反应。 关键调控分子：NF-κB（p65/p50）、IκBα、IKKα/β/γ、TNFα、LPS。

3553 (IL1B)7124 (TNF)1896 (EDA)1896 (EDA)3929 (LBP)23643 (LY96)959 (CD40LG)8600 (TNFSF11)4049 (LTA)4050 (LTB)8740 (TNFSF14)10673 (TNFSF13B)1896 (EDA)102723407 (IGH)3554 (IL1R1)7132 (TNFRSF1A)10913 (EDAR)60401 (EDA2R)929 (CD14)7099 (TLR4)958 (CD40)8792 (TNFRSF11A)4055 (LTBR)115650 (TNFRSF13C)60401 (EDA2R)3932 (LCK)7535 (ZAP70)27040 (LAT)5335 (PLCG1)6850 (SYK)4067 (LYN)29760 (BLNK)695 (BTK)5336 (PLCG2)4615 (MYD88)3654 (IRAK1), 51135 (IRAK4)7189 (TRAF6)8737 (RIPK1)8717 (TRADD)7186 (TRAF2), 7188 (TRAF5)329 (BIRC2), 330 (BIRC3)128178 (EDARADD)7189 (TRAF6)1540 (CYLD)7187 (TRAF3)7189 (TRAF6)23586 (RIGI)7706 (TRIM25)7186 (TRAF2), 7189 (TRAF6)114609 (TIRAP)4615 (MYD88)3654 (IRAK1), 51135 (IRAK4)7189 (TRAF6)353376 (TICAM2)148022 (TICAM1)8737 (RIPK1)7189 (TRAF6)7189 (TRAF6)7187 (TRAF3)7186 (TRAF2)329 (BIRC2), 330 (BIRC3)7189 (TRAF6)7186 (TRAF2)7186 (TRAF2)7188 (TRAF5)9020 (MAP3K14)7186 (TRAF2)7187 (TRAF3)7186 (TRAF2)7187 (TRAF3)7187 (TRAF3)329 (BIRC2), 330 (BIRC3)7189 (TRAF6)5588 (PRKCQ)5579 (PRKCB)29775 (CARD10), 79092 (CARD14), 84433 (CARD11)8915 (BCL10)10892 (MALT1)23085 (ERC1)8517 (IKBKG)1147 (CHUK)8517 (IKBKG)3551 (IKBKB)6885 (MAP3K7)10454 (TAB1), 23118 (TAB2), 257397 (TAB3)4792 (NFKBIA)10848 (PPP1R13L)4790 (NFKB1)5970 (RELA)695 (BTK)4792 (NFKBIA)4790 (NFKB1)5970 (RELA)1457 (CSNK2A1), 1459 (CSNK2A2), 1460 (CSNK2B), 283106 (CSNK2A3)4792 (NFKBIA)4790 (NFKB1)5970 (RELA)9020 (MAP3K14)1147 (CHUK)4791 (NFKB2)5971 (RELB)4791 (NFKB2)472 (ATM)8517 (IKBKG)142 (PARP1)51588 (PIAS4)7329 (UBE2I)8517 (IKBKG)55367 (PIDD1)8737 (RIPK1)329 (BIRC2), 330 (BIRC3)8837 (CFLAR)331 (XIAP)598 (BCL2L1)596 (BCL2)10912 (GADD45G), 1647 (GADD45A), 4616 (GADD45B)7185 (TRAF1), 7186 (TRAF2)597 (BCL2A1)4791 (NFKB2)3576 (CXCL8)3553 (IL1B)7124 (TNF)7128 (TNFAIP3)4792 (NFKBIA)5743 (PTGS2)388372 (CCL4L1), 6351 (CCL4), 9560 (CCL4L2)2919 (CXCL1), 2920 (CXCL2), 2921 (CXCL3)7412 (VCAM1)5328 (PLAU)598 (BCL2L1)598 (BCL2L1)597 (BCL2A1)6357 (CCL13)6363 (CCL19)6366 (CCL21)6387 (CXCL12)10673 (TNFSF13B)3383 (ICAM1)

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