快速订购
登录 / 注册

中文

English

PI3K-Akt signaling pathway - PI3K-Akt 信号通路

介导生长因子、细胞因子、黏附信号的关键通路，在细胞存活与增殖中起核心作用。生长因子结合受体后，激活 PI3K 催化磷脂酰肌醇（PI）磷酸化生成 PIP3，PIP3 招募 Akt 与 PDK1 至细胞膜，PDK1 磷酸化激活 Akt。激活的 Akt 通过磷酸化下游底物发挥功能：抑制 Bad、Caspase-9 等促凋亡分子，促进细胞存活；激活 mTOR、GSK3β，促进细胞增殖与代谢；调控 NF-κB 通路，增强细胞抗逆性。PTEN 是通路核心负调控因子，可降解 PIP3。通路异常激活（如 PI3K 突变、PTEN 缺失）是人类肿瘤中最常见的分子事件之一，与肺癌、乳腺癌、前列腺癌等密切相关，多种 PI3K、Akt 抑制剂已进入临床应用。
核心功能：介导生长因子信号，促进细胞增殖、存活、代谢与迁移，异常激活与肿瘤发生密切相关。 关键调控分子：PI3K、Akt1/2/3、PTEN、mTOR、GSK3β。

125467750 (EFNA4-EFNA3), 1435 (CSF1), 1942 (EFNA1), 1943 (EFNA2), 1944 (EFNA3), 1945 (EFNA4), 1946 (EFNA5), 1950 (EGF), 2069 (EREG), 2246 (FGF1), 2247 (FGF2), 2248 (FGF3), 2249 (FGF4), 2250 (FGF5), 2251 (FGF6), 2252 (FGF7), 2253 (FGF8), 2254 (FGF9), 2255 (FGF10), 2277 (VEGFD), 2323 (FLT3LG), 26281 (FGF20), 26291 (FGF21), 2668 (GDNF), 27006 (FGF22), 284 (ANGPT1), 285 (ANGPT2), 3082 (HGF), 3479 (IGF1), 3481 (IGF2), 3630 (INS), 374 (AREG), 4254 (KITLG), 4803 (NGF), 4902 (NRTN), 4908 (NTF3), 4909 (NTF4), 51378 (ANGPT4), 5154 (PDGFA), 5155 (PDGFB), 5228 (PGF), 56034 (PDGFC), 5623 (PSPN), 627 (BDNF), 7039 (TGFA), 7422 (VEGFA), 7423 (VEGFB), 7424 (VEGFC), 80310 (PDGFD), 8074 (FGF23), 8817 (FGF18), 8822 (FGF17), 8823 (FGF16), 9048 (ARTN), 9965 (FGF19)1436 (CSF1R), 1956 (EGFR), 1969 (EPHA2), 2064 (ERBB2), 2065 (ERBB3), 2066 (ERBB4), 2260 (FGFR1), 2261 (FGFR3), 2263 (FGFR2), 2264 (FGFR4), 2321 (FLT1), 2322 (FLT3), 2324 (FLT4), 3480 (IGF1R), 3643 (INSR), 3791 (KDR), 3815 (KIT), 4233 (MET), 4804 (NGFR), 4914 (NTRK1), 4915 (NTRK2), 5156 (PDGFRA), 5159 (PDGFRB), 5979 (RET), 7010 (TEK)2885 (GRB2)6654 (SOS1), 6655 (SOS2)3265 (HRAS), 3845 (KRAS), 4893 (NRAS)1440 (CSF3), 1442 (CSH1), 1443 (CSH2), 1444 (CSHL1), 2056 (EPO), 2688 (GH1), 2689 (GH2), 3439 (IFNA1), 3440 (IFNA2), 3441 (IFNA4), 3442 (IFNA5), 3443 (IFNA6), 3444 (IFNA7), 3445 (IFNA8), 3446 (IFNA10), 3447 (IFNA13), 3448 (IFNA14), 3449 (IFNA16), 3451 (IFNA17), 3452 (IFNA21), 3456 (IFNB1), 3558 (IL2), 3562 (IL3), 3565 (IL4), 3569 (IL6), 3574 (IL7), 5008 (OSM), 5617 (PRL)10319 (LAMC3), 1101 (CHAD), 1277 (COL1A1), 1278 (COL1A2), 1280 (COL2A1), 1282 (COL4A1), 1284 (COL4A2), 1285 (COL4A3), 1286 (COL4A4), 1287 (COL4A5), 1288 (COL4A6), 1291 (COL6A1), 1292 (COL6A2), 1293 (COL6A3), 1297 (COL9A1), 1298 (COL9A2), 1299 (COL9A3), 1311 (COMP), 131873 (COL6A6), 22798 (LAMB4), 2335 (FN1), 256076 (COL6A5), 284217 (LAMA1), 3371 (TNC), 3381 (IBSP), 3908 (LAMA2), 3909 (LAMA3), 3910 (LAMA4), 3911 (LAMA5), 3912 (LAMB1), 3913 (LAMB2), 3914 (LAMB3), 3915 (LAMC1), 3918 (LAMC2), 5649 (RELN), 63923 (TNN), 6696 (SPP1), 7057 (THBS1), 7058 (THBS2), 7059 (THBS3), 7060 (THBS4), 7143 (TNR), 7148 (TNXB), 7448 (VTN), 7450 (VWF)7097 (TLR2), 7099 (TLR4)102723407 (IGH)930 (CD19)1441 (CSF3R), 2057 (EPOR), 2690 (GHR), 3454 (IFNAR1), 3455 (IFNAR2), 3559 (IL2RA), 3560 (IL2RB), 3561 (IL2RG), 3563 (IL3RA), 3566 (IL4R), 3570 (IL6R), 3575 (IL7R), 5618 (PRLR), 9180 (OSMR)22801 (ITGA11), 3655 (ITGA6), 3672 (ITGA1), 3673 (ITGA2), 3674 (ITGA2B), 3675 (ITGA3), 3676 (ITGA4), 3678 (ITGA5), 3679 (ITGA7), 3680 (ITGA9), 3685 (ITGAV), 8515 (ITGA10), 8516 (ITGA8)3688 (ITGB1), 3690 (ITGB3), 3691 (ITGB4), 3693 (ITGB5), 3694 (ITGB6), 3695 (ITGB7), 3696 (ITGB8)10161 (LPAR6), 1128 (CHRM1), 1129 (CHRM2), 1902 (LPAR1), 2149 (F2R), 23566 (LPAR3), 2846 (LPAR4), 57121 (LPAR5), 9170 (LPAR2)10681 (GNB5), 2782 (GNB1), 2783 (GNB2), 2784 (GNB3), 2785 (GNG3), 2786 (GNG4), 2787 (GNG5), 2788 (GNG7), 2790 (GNG10), 2791 (GNG11), 2792 (GNGT1), 2793 (GNGT2), 51764 (GNG13), 54331 (GNG2), 55970 (GNG12), 59345 (GNB4), 94235 (GNG8)5747 (PTK2)3716 (JAK1), 3717 (JAK2), 3718 (JAK3)118788 (PIK3AP1)6850 (SYK)5879 (RAC1)3667 (IRS1)110117499 (P3R3URF-PIK3R3), 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3)146850 (PIK3R6), 23533 (PIK3R5), 5294 (PIK3CG)9223 (MAGI1), 9863 (MAGI2)5728 (PTEN)110117499 (P3R3URF-PIK3R3), 146850 (PIK3R6), 23533 (PIK3R5), 5290 (PIK3CA), 5291 (PIK3CB), 5293 (PIK3CD), 5294 (PIK3CG), 5295 (PIK3R1), 5296 (PIK3R2), 8503 (PIK3R3)5728 (PTEN)5170 (PDPK1)3320 (HSP90AA1), 3326 (HSP90AB1), 7184 (HSP90B1)11140 (CDC37)200186 (CRTC2)23035 (PHLPP2), 23239 (PHLPP1)4515 (MTCP1), 8115 (TCL1A), 9623 (TCL1B)117145 (THEM4)28227 (PPP2R3B), 55012 (PPP2R3C), 5515 (PPP2CA), 5516 (PPP2CB), 5518 (PPP2R1A), 5519 (PPP2R1B), 5520 (PPP2R2A), 5521 (PPP2R2B), 5522 (PPP2R2C), 5523 (PPP2R3A), 5525 (PPP2R5A), 5526 (PPP2R5B), 5527 (PPP2R5C), 5528 (PPP2R5D), 5529 (PPP2R5E), 55844 (PPP2R2D)10000 (AKT3), 207 (AKT1), 208 (AKT2)6794 (STK11)54541 (DDIT4)5562 (PRKAA1), 5563 (PRKAA2)7248 (TSC1)7249 (TSC2)6009 (RHEB)64223 (MLST8)2475 (MTOR)57521 (RPTOR)1978 (EIF4EBP1)6198 (RPS6KB1), 6199 (RPS6KB2)1977 (EIF4E), 253314 (EIF4E1B), 9470 (EIF4E2)1975 (EIF4B)6194 (RPS6)5578 (PRKCA)29941 (PKN3), 5585 (PKN1), 5586 (PKN2)100533105 (C8orf44-SGK3), 10110 (SGK2), 23678 (SGK3), 6446 (SGK1)4846 (NOS3)5894 (RAF1)5604 (MAP2K1), 5605 (MAP2K2)5594 (MAPK1), 5595 (MAPK3)672 (BRCA1)2932 (GSK3B)2997 (GYS1), 2998 (GYS2)5105 (PCK1), 5106 (PCK2)2538 (G6PC1), 57818 (G6PC2), 92579 (G6PC3)4609 (MYC)595 (CCND1)1026 (CDKN1A)1027 (CDKN1B)1017 (CDK2), 1019 (CDK4), 1021 (CDK6)595 (CCND1), 894 (CCND2), 896 (CCND3), 898 (CCNE1), 9134 (CCNE2)1027 (CDKN1B)5934 (RBL2)356 (FASLG)10018 (BCL2L11)2309 (FOXO3)10971 (YWHAQ), 7529 (YWHAB), 7531 (YWHAE), 7532 (YWHAG), 7533 (YWHAH), 7534 (YWHAZ)572 (BAD)598 (BCL2L1)596 (BCL2)842 (CASP9)596 (BCL2)4170 (MCL1)10488 (CREB3), 1385 (CREB1), 1386 (ATF2), 1388 (ATF6B), 148327 (CREB3L4), 468 (ATF4), 64764 (CREB3L2), 84699 (CREB3L3), 90993 (CREB3L1), 9586 (CREB5)6256 (RXRA)3164 (NR4A1)596 (BCL2)1147 (CHUK), 3551 (IKBKB), 8517 (IKBKG)4790 (NFKB1), 5970 (RELA)598 (BCL2L1)4602 (MYB)4193 (MDM2)7157 (TP53)

产品列表

    货号
    产品名称
    反应性
    应用
  • {{item.catalog}}
    {{item.title}}
    {{item.react}}
    {{item.applicat}}

Related Resource Links

Related Promotional Journal Downloads

Brand/Complete Product Range Series
Brand/Complete Product Range Series

Detailed introduction of the column

Download and Save
Primary antibodies
Primary antibodies

Detailed introduction of the column

Download and Save
Secondary antibodies
Secondary antibodies

Detailed introduction of the column

Download and Save
mIHC/ Multiplex Fluorescence Detection Kits
mIHC/ Multiplex Fluorescence Detection Kits

Detailed introduction of the column

Download and Save

热门产品推荐

更多产品
AR0002

AR0002
AR0003

AR0003
MH0001

MH0001
SH0003

SH0003
AH0001

AH0001
AH0002

AH0002
AH0003

AH0003
AR0001

AR0001

30000 + 优质产品矩阵，云端一站式尊享供应

一抗、二抗、mIHC试剂盒、ELISA试剂盒、蛋白、分子生物学产品、细胞培养相关产品、辅助试剂...

联系我们