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货号: AR0001
规格
价格
货期
数量
20ul
￥600.00
In stock
0
40ul
￥1,100.00
In stock
0
100ul
￥2,260.00
In stock
0
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Carrier-free/conjugated antibody/large package or custom formula
主要信息
靶点
GPX4
反应性
Human,Mouse,Rat
应用
WB,IHC,IF,ELISA
MW (kDa)
22kD（ Calculated）
22kD（ Observed）
宿主物种
Rabbit
同种型
IgG,Kappa
详细信息
反应性
IHC 1:200-1:1000
WB 1:2000-1:10000
IF 1:200-1:1000
ELISA 1:5000-1:20000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
特异性
Endogenous
纯化工艺
Protein A
储存
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
理论分子量
22kD
实测分子量
22kD
克隆性
Monoclonal
克隆号
R635P
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抗原&靶点信息
基因名称:
GPX4
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蛋白名称:
GPX4
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别名:
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial ;
PHGPx ;
Glutathione peroxidase 4 ;
GPx-4 ;
GSHPx-4 ;
PHGPx ;
Glutathione peroxidase 4 ;
GPx-4 ;
GSHPx-4 ;
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细胞定位
Cytoplasm
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组织表达
背景
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016],
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功能
Catalytic activity:2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O.,Disease:Defects in GPX4 may be a cause of infertility.,Function:Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.,similarity:Belongs to the glutathione peroxidase family.,subunit:Monomer. Has a tendency to form higher mass oligomers.,tissue specificity:Present primarily in testis.,
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研究领域
>> >>Glutathione metabolism ;
>> >>Metabolic pathways ;
>> >>Ferroptosis
>> >>Metabolic pathways ;
>> >>Ferroptosis
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