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货号: AH0002
规格
价格
货期
数量
20ul
￥540.00
In stock
0
40ul
￥1,000.00
In stock
0
100ul
￥2,080.00
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0
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Customized service consultation
Carrier-free/conjugated antibody/large package or custom formula
主要信息
靶点
Sox-9
反应性
Human,Mouse,Rat,Bovine
应用
IHC,ELISA
MW (kDa)
56kD（ Calculated）
70kD（ Observed）
宿主物种
Mouse
同种型
IgG2b,Kappa
详细信息
反应性
IHC 1:200-400
ELISA 1:500-5000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#RH0011)
抗体验证策略
特异性
The antibody can specifically recognize human SOX9 protein.
纯化工艺
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C, Ship by ice bag)
理论分子量
56kD
实测分子量
70kD
克隆性
Monoclonal
克隆号
M777J
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抗原&靶点信息
免疫原:
Synthesized peptide derived from human SOX9 AA range: 1-100
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基因名称:
SOX9
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蛋白名称:
Transcription factor SOX-9
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细胞定位
Nuclear
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组织表达
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背景
SRY-box 9(SOX9) Homo sapiens The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008],
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功能
Disease:Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage.,Function:Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.,similarity:Contains 1 HMG box DNA-binding domain.,
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研究领域
>> >>cAMP signaling pathway
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